Metalloproteinases and their inhibitors-diagnostic and therapeutic opportunities in orthopedics.

Authors: Pasternak B, Aspenberg P Matrix metalloproteinases (MMPs) and related enzymes (ADAMs, ADAMTS) and their inhibitors control matrix turnover and function. Recent advances in our understanding of musculoskeletal conditions such as tendinopathy, arthritis, Dupuytren's disease, degenerative disc disease, and bone and soft tissue healing suggest that MMPs have prominant roles. Importantly, MMPs are amenable to inhibition by cheap, safe, and widely available drugs such as the tetracycline antibiotics and the bisphosphonates. This indicates that these MMP inhibitors, if proven effective for any novel indication, may be quickly brought into clinical practice. PMID: 19968600 [PubMed - as supplied by publisher] (Source: Acta Orthopaedica)
Read More... [Source: MedWorm: Dupuytren's Contracture - Posted by FreeAutoBlogger]

Keloid scarring, but not Dupuytren's contracture, is associated with unexplained carotid atherosclerosis.

CONCLUSIONS: Keloid scarring is a clinical clue to excess atherosclerosis not explained by traditional risk factors. Such patients may benefit from therapy directed at targets related to signalling molecules common to both the process of keloid scarring and atherosclerosis. These findings suggest previously unexplored possibilities for the prevention and treatment of atherosclerosis. The differences between Dupuytren's and keloid scars that may identify such targets are discussed. PMID: 19331810 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Read More... [Source: MedWorm: Dupuytren's Contracture - Posted by FreeAutoBlogger]

Penicillium Candidum (White)1 pack Cheese Mold

$10.95 End Date: Monday Nov-23-2009 14:09:05 PST Buy It Now for only: US $10.95 Buy it now | Add to watch list

Read More... [Source: RMCrafts Store Front - Posted by FreeAutoBlogger]

Auxilium Pharmaceuticals, Inc. Announces First Patients Dosed in XIAFLEX(TM) U.S. Pivotal Phase III Study

Enrollment in Australian Phase III Trial Also Has CommencedMALVERN, PA--Sep 10, 2007 -- Auxilium Pharmaceuticals, Inc. (NasdaqGM:AUXL ) today announced that the first patients have been dosed in the Company's second U.S. phase III pivotal trial and the... BiopharmaceuticalsAuxilium Pharmaceuticals, XIAFLEX, Dupuytren's contracture, U.S. CORD 1 (Source: HSMN NewsFeed)
Read More... [Source: MedWorm: Dupuytren's Contracture - Posted by FreeAutoBlogger]

Enzyme injections may treat Dupuytren's contracture

Scientists believe that injections of an enzyme called collagenase may help to treat a condition called Dupuytren's contracture, which causes the fingers to bend and fail to extend properly. (Source: Arthritis Research Campaign)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Read More... [Source: MedWorm: Dupuytren's Contracture - Posted by FreeAutoBlogger]

Auxilium Pharmaceuticals, Inc.: Auxilium Submits Biologics License Application for XIAFLEX(TM) for the Treatment of Dupuytren's Contracture to the U.S. Food and Drug Administration

MALVERN, PA (MARKET WIRE) Auxilium Pharmaceuticals, Inc. (NASDAQ: AUXL), a specialty biopharmaceutical company, today announced that it has submitted a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for XIAFLEX(TM) (clostridial collagenase for injection), a novel, first-in-class, orphan-designated biologic for the treatment of Dupuytren's contracture. (Source: Market Wire - Pharmaceuticals and Biotech)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Read More... [Source: MedWorm: Dupuytren's Contracture - Posted by FreeAutoBlogger]

The lateral digital flap for Dupuytren's fasciectomy at the proximal interphalangeal joint - A study of 84 consecutive patients.

Authors: Anwar MU, Al Ghazal SK, Boome RS Fasciectomy is the most common operation performed for Dupuytren's disease. However, as the joint contracture increases, issues of skin deficiency following release become significant. For severe or recurrent disease dermafasciectomy is advised, but a digital transposition flap provides a viable alternative without the need for a skin graft for less-severe disease with moderate skin deficiency. A retrospective review identified 84 patients who had undergone this operation. The flap used was proximally based on the midlateral aspect of the finger allowing direct closure of the donor site. Ninety hands with 134 digits were operated on and 83% of the patients had a full correction. About 70% remained fully corrected at 1 year. All flaps were perfo...
Read More... [Source: MedWorm: Dupuytren's Contracture - Posted by FreeAutoBlogger]

Dupuytren�s disease of the radial side of the hand

Abstract  Dupuytren�s disease with involvement of the radial aspect of the hand is a clinical entity, which affects the thumb, the first web space, and the index finger. It can be primary or secondary. The palmar fascia anatomy and the clinical aspects of radial Dupuytren�s disease are described. The authors propose a new classification, which has the advantage in requiring only a clinical evaluation. One hundred and fifteen patients were examined for Dupuytren�s disease with radial involvement, primary or secondary, in the Hand Surgery Unit of the University of Modena between 1985 and 1994. Eighty-two (68.3%) of them were treated surgically as hand function was compromised by first web retraction. The most commonly used incisions of the first commissure are straight-l...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Read More... [Source: MedWorm: Dupuytren's Contracture - Posted by FreeAutoBlogger]

Guillaume Dupuytren (1777-1835) and his contracture

(Source: Journal of Medical Biography)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Read More... [Source: MedWorm: Dupuytren's Contracture - Posted by FreeAutoBlogger]

FDA gives priority review to Auxilium�s Xiaflex

The Food and Drug Administration granted priority review status to a new drug application filed by Auxilium Pharmaceuticals Inc. for Xiaflex, an experimental treatment for Dupuytren�s contracture. (AUXL) (Source: bizjournals.com Health Care:Health Insurance headlines)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Read More... [Source: MedWorm: Dupuytren's Contracture - Posted by FreeAutoBlogger]

Injectable collagenase clostridium histolyticum for Dupuytren's contracture

In this study the authors sought to evaluate injection of collagenase clostridium histolyticum into the affected cord as a potential non-surgical option; in previous single-centre studies this has been shown to reduce contractures (works by lysing collagen).    A total ... (Source: NeLM - News)
Read More... [Source: MedWorm: Dupuytren's Contracture - Posted by FreeAutoBlogger]

FDA gives priority review to Auxilium�s Xiaflex

The Food and Drug Administration granted priority review status to a new drug application filed by Auxilium Pharmaceuticals Inc. for Xiaflex, an experimental treatment for Dupuytren�s contracture. (AUXL) (Source: bizjournals.com Health Care:Industry Regulation headlines)
Read More... [Source: MedWorm: Dupuytren's Contracture - Posted by FreeAutoBlogger]

Collagenase Injections Can Improve Range of Motion

Injection of collagenase clostridium histolyticum into the affected hand joints of patients with Dupuytren's disease can reduce joint contracture, improve range of motion, and provide an office-based alternative to risky hand surgery, according to a study in the Sept. 3 issue of the New England Journal of Medicine. (Source: Modern Medicine)
Read More... [Source: MedWorm: Dupuytren's Contracture - Posted by FreeAutoBlogger]

Curved Penis Cures and Remedies

Peyronie's disease is a condition in which a plaque (a thickened, hardened piece of tissue) forms on one side of the penis. If the plaque becomes large enough, it reduces flexibility of the pe...
Read More... [Source: GoArticles Search for 'Dupuytren Contracture' - Posted by FreeAutoBlogger]