Metalloproteinases and their inhibitors-diagnostic and therapeutic opportunities in orthopedics.

Authors: Pasternak B, Aspenberg P Matrix metalloproteinases (MMPs) and related enzymes (ADAMs, ADAMTS) and their inhibitors control matrix turnover and function. Recent advances in our understanding of musculoskeletal conditions such as tendinopathy, arthritis, Dupuytren's disease, degenerative disc disease, and bone and soft tissue healing suggest that MMPs have prominant roles. Importantly, MMPs are amenable to inhibition by cheap, safe, and widely available drugs such as the tetracycline antibiotics and the bisphosphonates. This indicates that these MMP inhibitors, if proven effective for any novel indication, may be quickly brought into clinical practice. PMID: 19968600 [PubMed - as supplied by publisher] (Source: Acta Orthopaedica)
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Keloid scarring, but not Dupuytren's contracture, is associated with unexplained carotid atherosclerosis.

CONCLUSIONS: Keloid scarring is a clinical clue to excess atherosclerosis not explained by traditional risk factors. Such patients may benefit from therapy directed at targets related to signalling molecules common to both the process of keloid scarring and atherosclerosis. These findings suggest previously unexplored possibilities for the prevention and treatment of atherosclerosis. The differences between Dupuytren's and keloid scars that may identify such targets are discussed. PMID: 19331810 [PubMed - in process] (Source: Clinical and Investigative Medicine)
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Penicillium Candidum (White)1 pack Cheese Mold

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Auxilium Pharmaceuticals, Inc. Announces First Patients Dosed in XIAFLEX(TM) U.S. Pivotal Phase III Study

Enrollment in Australian Phase III Trial Also Has CommencedMALVERN, PA--Sep 10, 2007 -- Auxilium Pharmaceuticals, Inc. (NasdaqGM:AUXL ) today announced that the first patients have been dosed in the Company's second U.S. phase III pivotal trial and the... BiopharmaceuticalsAuxilium Pharmaceuticals, XIAFLEX, Dupuytren's contracture, U.S. CORD 1 (Source: HSMN NewsFeed)
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Enzyme injections may treat Dupuytren's contracture

Scientists believe that injections of an enzyme called collagenase may help to treat a condition called Dupuytren's contracture, which causes the fingers to bend and fail to extend properly. (Source: Arthritis Research Campaign)

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Auxilium Pharmaceuticals, Inc.: Auxilium Submits Biologics License Application for XIAFLEX(TM) for the Treatment of Dupuytren's Contracture to the U.S. Food and Drug Administration

MALVERN, PA (MARKET WIRE) Auxilium Pharmaceuticals, Inc. (NASDAQ: AUXL), a specialty biopharmaceutical company, today announced that it has submitted a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for XIAFLEX(TM) (clostridial collagenase for injection), a novel, first-in-class, orphan-designated biologic for the treatment of Dupuytren's contracture. (Source: Market Wire - Pharmaceuticals and Biotech)

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The lateral digital flap for Dupuytren's fasciectomy at the proximal interphalangeal joint - A study of 84 consecutive patients.

Authors: Anwar MU, Al Ghazal SK, Boome RS Fasciectomy is the most common operation performed for Dupuytren's disease. However, as the joint contracture increases, issues of skin deficiency following release become significant. For severe or recurrent disease dermafasciectomy is advised, but a digital transposition flap provides a viable alternative without the need for a skin graft for less-severe disease with moderate skin deficiency. A retrospective review identified 84 patients who had undergone this operation. The flap used was proximally based on the midlateral aspect of the finger allowing direct closure of the donor site. Ninety hands with 134 digits were operated on and 83% of the patients had a full correction. About 70% remained fully corrected at 1 year. All flaps were perfo...
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